Eleven people were injured after a large explosion occurred at a commercial facility in Louisville, Kentucky, on Tuesday afternoon, officials said.

Two people were rescued from the Givaudan Sense Colour facility in the Clifton neighborhood, and those injured were all employees working in the plant, Louisville Mayor Craig Greenberg said at a news conference.

All employees working in and around the facility have since been accounted for, the mayor said.

The large explosion was heard in the city at around 3 p.m. ET and local agencies began responding to a “large scale incident” involving hazardous materials, the Louisville Fire Department said on X.

Officials issued a shelter-in-place order for people within a one-mile radius of the site in the Clifton neighborhood and an evacuation order for houses for the two surrounding blocks.

Aerial video from CNN affiliate WLKY showed massive damage to a commercial building.

Greenberg said employees who were inside the building reported “normal activity when the explosion occurred,” adding the cause of the explosion is under investigation.

At least six patients were transported to the emergency department at University of Louisville Hospital, which told CNN it activated “decontamination unit/procedures” and the fire department is also at the hospital “assisting with decontamination.”

Givaudan Colour Sense is a company that makes “natural colours for multisensorial food and beverage experiences,” according to its website.

The shelter-in-place order was being lifted, the mayor said late Tuesday afternoon, but he urged residents in the area to “err on the side of caution.”

The city is also using a drone to monitor air quality in the area, said Executive Director of Louisville Metro Emergency Services Jody Meimen.

This is a developing story and will be updated.